Patients fitted with long-term bladder catheters are often encountered a potentially serious complications caused by a gram-negative bacteria mirabilis romance that could colonising the probes-guides. A further complication caused by p. mirabilis is biofilm formation and probe with struvite crystals encrustation resulting in slowed or blocked urinary flow. If left unresolved the blockage can lead to bacteriuria, pyelonephritis and sepsis.
In a research study presented at the annual Interscience Conference on antimicrobial agents and chemotherapy (ICAAC), a team led by Dr. Dmitri Debabov head of cell and microbiology NovaBay Pharmaceuticals investigates the potential use of a non-antibiotic, anti-infective compound NVC-422. The company uses an in vitro model to imitate a catheterized bladder suffering P. mirabilis resulting in struvite encrustation.NVC-422 was able to prevent the growth and the resulting struvite formation in these chambers for bladder catheterized up to 144 hours versus alatwdes checks excluded to 46 hours; electron microscopy has confirmed that these probes were excluded due to the accumulation of biofilm and struvite.
Dr. Ron Najafi, President & CEO of NovaBay, said, "patients with long-term indwelling bladder catheters are often face severe Bacterial colonization, causing encrustation and subsequent probe blockage. current methods for unblock these probes are mechanically using atomizing or using agents trying to dissolve the struvite crystals. Unfortunately neither method provides satisfactory results. "
NovaBay estimates that more than 300,000 patients suffering from multiple sclerosis or spinal cord injuries in paraplegia or quadriplegia in stroke and use Foley catheters-guides these patients are at risk; a daily for development related to probe a urinary tract infection contaminations. P.mirabilis quickly can develop a strong biofilm resulting in stone and probe encrustation of NovaBay non-antibiotic, anti-infective deals directly with this and other bacteria in the bladder without providing an opportunity for the development of resistance and will maintain probe patency.
"The discovery research suggests that NVC-422 is a powerful, act fast, broad-spectrum antimicrobial agent with the potential to kill p. mirabilis and thus on the competitiveness of the formation of struvite crystals and subsequent probe gridlock," said Dr. Najafi.
For more information, log on to www.novabaypharma.com
9afbc14c-f09d-437f-a7ff-3fd5aa93d12a | 0 |.0Posted: Device/Technology News | Disease/virus NewsTags: Antibiotics, probe, CEng, chemotherapy, microscopy, multiple sclerosis, paraplegia, Pyelonephritis, Quadriplegia, sepsis, stroke
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